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LANTUS (INSULIN GLARGINE): DRUG INTERACTIONS

A number of drugs affect glucose metabolism and may require insulin dose adjustment and particularly close monitoring.

The following are examples of drugs that may increase the blood-glucose-lowering effect of insulins including Lantus (Insulin Glargine) injections and, therefore, increase the susceptibility to hypoglycemia: oral anti-diabetic products, pramlintide, angiotensin converting enzyme (ACE) inhibitors, fibrates, disopyramide, fluoxetine, propoxyphene, pentoxifylline, monoamine oxidase inhibitors, salicylates, somatostatin analogs, and sulfonamide antibiotics.

The following are examples of drugs that may reduce the blood-glucose-lowering effect of insulins including Lantus insulin injections: niacin, corticosteroids, diuretics, danazol, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), isoniazid, glucagon, phenothiazine derivatives, thyroid hormones, somatropin, estrogens, progestogens (e.g., in oral contraceptives), protease inhibitors and atypical antipsychotic medications (e.g. olanzapine and clozapine).

Beta-blockers, lithium salts, clonidine, and alcohol may either potentiate or weaken the bloodglucose-lowering effect of insulin. Pentamidine may cause hypoglycemia, which may sometimes be followed by hyperglycemia.

The signs of hypoglycemia may be reduced or absent in patients taking sympatholytic drugs such as beta-blockers, clonidine, guanethidine, and reserpine.

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