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LANTUS (INSULIN GLARGINE): CLINICAL STUDIES

The safety and effectiveness of Insulin Glargine (Lantus) injections given once-daily at bedtime was compared to that of once-daily and twice-daily NPH insulin in open-label, randomized, active-controlled, parallel studies of 2,327 adult patients and 349 pediatric patients with type 1 diabetes mellitus and 1,563 adult patients with type 2 diabetes mellitus. In general, the reduction in glycated hemoglobin (HbA1c) with Lantus injections was similar to that with NPH insulin. The overall rates of hypoglycemia did not differ between patients with diabetes treated with Insulin Glargine injections compared to NPH insulin.

Type 1 Diabetes. Adult.

In two clinical studies (Studies A and B), patients with type 1 diabetes (Study A; n=585, Study B; n=534) were randomized to 28 weeks of basal-bolus treatment with Lantus or NPH insulin. Regular human insulin was administered before each meal. Lantus Insulin was administered at bedtime. NPH insulin was administered once daily at bedtime or in the morning and at bedtime when used twice daily. In another clinical study (Study C), patients with type 1 diabetes (n=619) were randomized to 16 weeks of basal-bolus treatment with Insulin Glargine or NPH insulin. Insulin lispro was used before each meal. Lantus (Insulin Glargine) was administered once daily at bedtime and NPH insulin was administered once or twice daily. In these 3 studies, Lantus and NPH insulin had similar effects on HbA1c with a similar overall rate of hypoglycemia.

Type 1 Diabetes. Pediatric.

In a randomized, controlled clinical study (Study D), pediatric patients (age range 6 to 15 years) with type 1 diabetes (n=349) were treated for 28 weeks with a basal-bolus insulin regimen where regular human insulin was used before each meal. Insulin Glargine (Lantus) was administered once daily at bedtime and NPH insulin was administered once or twice daily. Similar effects on HbA1c and the incidence of hypoglycemia were observed in both treatment groups.

Type 2 Diabetes. Adult.

In a randomized, controlled clinical study (Study E) (n=570), Lantus (Insulin Glargine) injections was evaluated for 52 weeks in combination with oral anti-diabetic medications (a sulfonylurea, metformin, acarbose, or combinations of these drugs). Lantus insulin injections administered once daily at bedtime was as effective as NPH insulin administered once daily at bedtime in reducing HbA1c and fasting glucose. The rate of hypoglycemia was similar in Lantus and NPH insulin treated patients. In a randomized, controlled clinical study (Study F), in patients with type 2 diabetes not using oral anti-diabetic medications (n=518), a basal-bolus regimen of Lantus (Insulin Glargine) injections 100 IU / ml once daily at bedtime or NPH insulin administered once or twice daily was evaluated for 28 weeks. Regular human insulin was used before meals, as needed. Insulin Glargine (Lantus) injections had similar effectiveness as either once- or twice-daily NPH insulin in reducing HbA1c and fasting glucose with a similar incidence of hypoglycemia. In a randomized, controlled clinical study (Study G), patients with type 2 diabetes were randomized to 5 years of treatment with once-daily Lantus injections or twice-daily NPH insulin. For patients not previously treated with insulin, the starting dose of Insulin Glargine injections or NPH insulin was 10 units daily. Patients who were already treated with NPH insulin either continued on the same total daily NPH insulin dose or started Lantus at a dose that was 80% of the total previous NPH insulin dose. The primary endpoint for this study was a comparison of the progression of diabetic retinopathy by 3 or more steps on the Early Treatment Diabetic Retinopathy Study (ETDRS) scale. HbA1c change from baseline was a secondary endpoint. Similar glycemic control in the 2 treatment groups was desired in order to not confound the interpretation of the retinal data. Patients or study personnel used an algorithm to adjust the Lantus and NPH insulin doses to a target fasting plasma glucose <= 100 mg / dl. After the Lantus Insulin or NPH insulin dose was adjusted, other anti-diabetic agents, including pre-meal insulin were to be adjusted or added. The Lantus group had a smaller mean reduction from baseline in HbA1c compared to the NPH insulin group, which may be explained by the lower daily basal insulin doses in the Lantus group. Both treatment groups had a similar incidence of reported symptomatic hypoglycemia.

Lantus Timing of Daily Dosing.

The safety and efficacy of Insulin Glargine administered pre-breakfast, pre-dinner, or at bedtime were evaluated in a randomized, controlled clinical study in patients with type 1 diabetes (study H, n=378). Patients were also treated with insulin lispro at mealtime. Lantus (Insulin Glargine) administered at different times of the day resulted in similar reductions in HbA1c compared to that with bedtime administration. In these patients, data are available from 8-point home glucose monitoring. The maximum mean blood glucose was observed just prior to injection of Insulin Glargine (Lantus) regardless of time of administration. In this study, 5% of patients in the Lantus-breakfast arm discontinued treatment because of lack of efficacy. No patients in the other two arms discontinued for this reason. The safety and efficacy of Lantus (Insulin Glargine) injections administered pre-breakfast or at bedtime were also evaluated in a randomized, active-controlled clinical study (Study I, n=697) in patients with type 2 diabetes not adequately controlled on oral anti-diabetic therapy. All patients in this study also received glimepiride 3 mg daily. Lantus insulin injections given before breakfast was at least as effective in lowering HbA1c as Lantus (Insulin Glargine) injections 100 IU / ml given at bedtime or NPH insulin given at bedtime.

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